Ascentage Pharma Entered into Clinical Collaboration with AstraZeneca for Lisaftoclax + Acalabrutinib in Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Shots:
- The companies collaborated to conduct a registrational P-III study of APG-2575 (Bcl-2 inhibitor) + AstraZeneca's Calquence (BTK) inhibitor) vs immunochemotherapy in treatment-naive patients with 1L CLL/SLL
- In the P-II study, lisaftoclax + acalabrutinib showed strong therapeutic potential with an ORR of 98% in patients with r/r CLL/SLL, ORR (100%) in treatment-naïve patients with an excellent safety profile The results were presented at ASH 2022
- Lisaftoclax is being studied in multiple clinical studies globally. Acalabrutinib was approved in 50+ countries/regions i.e., EU and Japan; was also approved for 2 indications incl. patients with MCL and adult patients with CLL/SLL
Ref: PR Newswire | Image: Ascentage
Related News:- Ascentage Pharma to Present P-II Study Results of Lisaftoclax (APG-2575) for Chronic Lymphocytic Leukemia at ASH 2022
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